{"id":75,"date":"2007-10-07T21:53:24","date_gmt":"2007-10-08T04:53:24","guid":{"rendered":"http:\/\/www.bigroom.org\/wordpress\/?p=75"},"modified":"2008-05-31T21:38:33","modified_gmt":"2008-06-01T04:38:33","slug":"libel-blasphemy-slander","status":"publish","type":"post","link":"http:\/\/www.bigroom.org\/wordpress\/?p=75","title":{"rendered":"Libel!  Blasphemy!  Slander!&#8230;"},"content":{"rendered":"<p>Injustice!  Perfidy!  HUMBUG!<\/p>\n<p>Periodically, someone puts up a &#8220;could you pass a grade-school science class&#8221; quiz.  The one linked to the image below goes to one that I just broke down and took, purely out of curiousity.  Take a look at this outrage!:<\/p>\n<p><a href=\"http:\/\/www.justsayhi.com\/bb\/science\"><img decoding=\"async\" src=\"http:\/\/www.justsayhi.com\/bb\/css\/img\/science\/badges\/a.jpg\" border=\"0\" alt=\"JustSayHi - Science Quiz\" \/><\/a><\/p>\n<p>Oh, sure, it LOOKS good, but what you <em>don&#8217;t<\/em> see is that it only gave me a 96%, implying that I missed one (it was a short quiz)!  Sure, the quiz was very much in the modern fashion for &#8220;standardized testing&#8221; (aka the &#8220;No Child Left Awake&#8221; project) where the emphasis is on memorizing stuff for a test rather than actual comprehension.  So, I thought, maybe I hadn&#8217;t correctly memorized which word was correct for one of the word-memorization questions.  But, no, according to the &#8220;answer sheet&#8221;, the one I supposedly got wrong was this one:<\/p>\n<p>(Note: If you&#8217;re planning to actually take that quiz, do so now before you read on and I give away one of the answers&#8230;)<\/p>\n<p>&#8220;How do mammals respire?&#8221;<\/p>\n<p>The options were:<\/p>\n<ul>\n<li>Aerobically<\/li>\n<li>Anaerobically<\/li>\n<li>Both aerobically and anaerobically<\/li>\n<\/ul>\n<p>Come on, I may hardly ever concern myself with perverse eukaryotic systems but&#8230;never mind just &#8220;mammals&#8221;, as far as I know, all <em>eukaryotes (animals, plants, and fungi)<\/em> only possess aerobic (oxygen-requiring) respiratory systems.<\/p>\n<p>However, the &#8220;answer sheet&#8221; for the quiz claims that the answer is &#8220;Both aerobically and anaerobically&#8221;.<\/p>\n<p>So&#8230;.they&#8217;re wrong.  I&#8217;m <em>pretty<\/em> sure what what they were intending to ask, given this answer, is &#8220;what kind of metabolism do mammals have?&#8221;, in which case their answer is correct.<\/p>\n<p>See, &#8220;respiration&#8221; is only one part of the cellular energy-generating system.  Specifically, it&#8217;s our friend, the Electron Transport Chain, which (to grossly oversimplify) harnesses the energy of oxygen sucking electrons off the end of the chain various biochemicals to recharge molecules of <span class=\"moreinfo\" title=\"Adenosine TriPhosphate.  The energy released when ATP releases that third phosphate to become Adenoside DiPhosphate provides the cell with energy that powers all kinds of cellular activity.\" onclick=\"alert(this.title);\">ATP<\/span>.  That&#8217;s <span class=\"moreinfo\" title=\"It's not even the only way a cell can respire, if you're considering bacteria and archaea.  Some of them can respire with things other than oxygen, such as nitrate, sulfate, and ferric iron [rust].  Pretty neat, huh?  Now you know why I'm more interested in prokaryotes...\" onclick=\"alert(this.title);\">not the only way a cell can get ATP<\/span>, though.  What the quiz authors are presumably alluding to is that there are non-oxygen-requiring biochemical pathways that animal cells can take to make energy &#8211; such as the one your muscles use when they can&#8217;t get enough oxygen, which involves production of lactic acid, which in turn gets blamed for the &#8220;burn&#8221; sensation you get when you work your muscles hard.<\/p>\n<p>So, the authors of this quiz are bad, bad people, besmirching my reputation and harming my precious self-esteem by giving me less than 100% on that quiz!<\/p>\n<p>On a <span class=\"moreinfo\" title=\"At least in the sense that it gives me a convenient bridge to my next rant...\" onclick=\"alert(this.title);\">related<\/span> subject: breathing causes cancer in Sprague-Dawley? rats!<\/p>\n<p>No, seriously, it&#8217;s true &#8211; try raising one group of Sprague-Dawley? rats with air, and one group with no air, and examing both populations 150 days later.  I guarantee you&#8217;ll find many more cancerous growths in the &#8220;with air&#8221; group than in the group that was denied air to breathe&#8230;<\/p>\n<p>What brought this outburst on?  It was <a title=\"Panicked article about a study on Aspartame carcinogenicity\" href=\"http:\/\/dmiessler.com\/blogarchive\/no-its-for-real-aspartame-causes-cancer\">this blog article<\/a>.  &#8220;No, It&#8217;s for Real: Aspartame Causes Cancer&#8221;, the post proclaims.  They&#8217;re talking about <a title=\"First Experimental Demonstration of the Multipotential Carcinogenic Effects of Aspartame Administered in the Feed to Sprague-Dawley Rats\" href=\"http:\/\/www.ramazzini.it\/fondazione\/pdfUpload\/Environ%20Health%20Perspect%20114%20379-385_2006.pdf\">This study(pdf)<\/a>.  Go ahead, take a look, but in particular, look at the tables of actual data, not the paper&#8217;s abstract.  In particular, take a look at Figure 1, especially &#8220;D&#8221; and &#8220;E&#8221; (showing survival rates for the different groups of Sprague-Dawley? rats as the study progressed), and at the number of &#8220;tumor-bearing animals&#8221; in Table 2.<\/p>\n<p>Notice that at around 120 days on the survival graphs, the groups with the highest percentage of members still alive <em>were the groups receiving the <strong>most<\/strong> aspartame<\/em> in their feed.  It&#8217;s worth noting that the highest-Aspartame group there was getting roughly the equivalent of a human drinking &lt;em&gt;thousands&lt;\/em&gt; of cans of diet soda every day.  Also note, in fairness, that both graphs seem to show little difference between the groups, so rather than assuming that Aspartame makes Sprague-Dawley? rats live longer, I would tend to assume that there&#8217;s really not much difference.<\/p>\n<p>Notice also that in terms of the percentage of Sprague-Dawley? rats that developed one or more tumors, there were <em>fewer<\/em> of them in the group that got the equivalent of 500 mg\/kg of aspartame: which scaled up to human terms means about 200-250 cans of diet soda EVERY DAY worth of aspartame.<\/p>\n<p>You may be wondering why I keep mentioning Sprague-Dawley?.  It&#8217;s because this is a particular commercially-bred strain of rat that&#8217;s popular with labs for this kind of thing.  One point that isn&#8217;t always mentioned is this: Sprague-Dawley? rats are <em>known to be prone to developing cancer<\/em> spontaneously.  This can be handy if you&#8217;re doing studies of &#8220;borderline&#8221; carcinogens.  The hope is that if something has even a tiny ability to cause cancer, you&#8217;ll be able to measure the effect in a population of critters known to get cancer at the drop of a metaphorical hat, when in a human population the incidence might be so rare that you can&#8217;t distinguish it from random chance.  To my admittedly-not-big-on-the-biochemistry-of-perverse-eukaryotes mind, this study really seems to show that there&#8217;s little or no effect &#8211; and certainly no dose-dependent effect &#8211; of aspartame even on cancer-prone lab rats.<\/p>\n<p>I don&#8217;t know what it is, but &#8220;artificial sweeteners&#8221;, and especially aspartame, seem to generate such passionate hatred in some people.  It reminds me a great deal of people&#8217;s reactions to <span class=\"moreinfo\" title=\"I can actually think of several legitimate concerns that apply to 'genetically-modified' crops...but none of them have anything to do with the crops being 'genetically-modified'.  For example, monoculture farming is bad regardless of whether your crop is genetically-modified or not.\" onclick=\"alert(this.title);\">&#8220;genetically modified&#8221; crops<\/span>. People just really <em>want<\/em> to hate it.  The authors of this paper are obviously trying REALLY hard to show somehow that aspartame is a dangerous poison, despite the inconclusive-appearing actual results.  Though I suppose one could argue that they showed Aspartame to be at least <a title=\"Is Expired JellO a deadly poison?\" href=\"http:\/\/www.bigroom.org\/wordpress\/?p=63\">as much of a deadly poison as Expired JellO?.<\/a><\/p>\n<p>And now that I have exposed my readers to several times the Recommended Daily Allowance of Humbug, I bid you all a good night &#8211; I have Art History and Philosophy to attend in the morning&#8230;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Injustice! Perfidy! HUMBUG! Periodically, someone puts up a &#8220;could you pass a grade-school science class&#8221; quiz. The one linked to the image below goes to one that I just broke down and took, purely out of curiousity. Take a look at this outrage!: Oh, sure, it LOOKS good, but what you don&#8217;t see is that &hellip; <a href=\"http:\/\/www.bigroom.org\/wordpress\/?p=75\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Libel!  Blasphemy!  Slander!&#8230;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9,22,14,15,6,5,11,7,17,8],"tags":[],"class_list":["post-75","post","type-post","status-publish","format-standard","hentry","category-food-science","category-freakish-eukaryotes","category-grossly-oversimplified-science","category-methods","category-microbiology","category-nerdity","category-rant","category-science-philosophy","category-teaching-science","category-why-does-it-work"],"_links":{"self":[{"href":"http:\/\/www.bigroom.org\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/75","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.bigroom.org\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.bigroom.org\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.bigroom.org\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.bigroom.org\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=75"}],"version-history":[{"count":0,"href":"http:\/\/www.bigroom.org\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/75\/revisions"}],"wp:attachment":[{"href":"http:\/\/www.bigroom.org\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=75"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.bigroom.org\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=75"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.bigroom.org\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=75"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}